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MLMLYS

Mineralys Therapeutics, Inc.

$MLYS·$2.3B·Biotechnology·Healthcare
$29.04+13.6%1Y-11.4%
Mentions · last 7 days
2026-08-26: 0 posts2026-08-27: 0 posts2026-08-28: 3 posts2026-08-29: 2 posts2026-08-30: 0 posts2026-08-31: 5 posts2026-09-01: 5 posts35
Price updated 1h ago·X counts updated 3h ago
MLMLYS
$MLYSMineralys Therapeutics, Inc.
$29.04+13.57%35 posts
AI analysisFundamentalsVoices on X
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AI verdict & sentimentAI analysisGenerated by AI from underlying data

Top X posts

Today's AI verdict on what's driving $MLYS, plus how loud the X conversation is and which way it's leaning.

AI analysis

TickerTalks’ read on the fundamentals and what’s driving the move.

Hinges on a big eventWinding up for a moveAI verdict · as of 2026-09-02

Trading in a tight range and building pressure — a move looks likely soon, but the direction isn't clear yet.

Mineralys cardiometabolic biotech — Q2 EPS missed by 420% but CPPIB (9/1) and BlackRock (8/29) both took new positions.

Mineralys Therapeutics is a clinical-stage cardiometabolic biotech (lorundrostat for hypertension) — PE -6x, down 11% t12m to 33% of the 52-week range and sitting 4% below the 50-day. Q2 EPS of -$2.85 missed the -$0.55 estimate by 420% (large clinical-development spend). Fresh 9/1 CPPIB new position, 8/29 BlackRock new position, 8/12 CMO Ferguson Form 3, 8/26 Wells Fargo Healthcare Conference participation.

  • The commercial base is zero: $0 revenue across trailing four quarters — a pre-revenue biotech burning $33M in Q2 FCF, with FY26 revenue consensus of just $557K jumping to $121M FY27, $255M FY28, and $682M FY29 on the lorundrostat approval-and-launch trajectory in resistant hypertension.
  • The Q2 miss was substantial but reflects clinical timing: EPS of -$2.85 versus -$0.55 estimate missed by 420% — this reflects increased spend on lorundrostat Phase 3 trials rather than commercial deterioration, and the FY26 EPS consensus of -$2.31 already incorporates aggressive R&D spend.
  • The CPPIB plus BlackRock fresh positions are meaningful institutional validation: 9/1 CPPIB and 8/29 BlackRock both taking new positions — this is exactly the sovereign/mega-institutional flow that supports the multi-year cardiometabolic thesis, alongside the 8/12 CMO Ferguson appointment.

The coiling below the 50-day resolves at 11/9 Q3 or a lorundrostat readout. A Phase 3 hypertension milestone extends the run; safety signal or dilution surprise breaks it back to the 52-week lows.

What to watch: 11/9 Q3 earnings OR a lorundrostat clinical readout. A positive Phase 3 hypertension milestone extends the run; a safety signal or fresh dilution surprise breaks the setup back to the 52-week lows.

On the calendar: 2026-11-09 - Q3 2026 earnings

Read the AI verdict + X sentiment for $MLYS

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What it does

Plain-English summary of the business — what they sell and how they make money.

Clinical-stage biotech developing lorundrostat, an oral aldosterone synthase inhibitor for hypertension and related cardiovascular diseases.

Industry overviewAI analysisGenerated by AI from underlying data

Where Biotechnology sits in its cycle right now — and what that implies for $MLYS.

Biotechnology · Healthcare

GLP-1 oral formulation competition — emerging clinical data from pipeline challengers — is the central bifurcation: platform holders (LLY, NVO) defend on efficacy breadth while precision oncology names decouple entirely. FDA catalyst cadence over the next 60 days sets the near-term tone.

What this means for $MLYS

Partial — branded pharmaceutical revenue is exposed to patent cliff dynamics and GLP-1 category cannibalization; Mineralys Therapeutics, Inc.

Top industry ETF

$IBBiShares Biotechnology ETF
+12.1%YTD
+50.1%1Y

Fundamentals & catalyst

Profitability, valuation, and the next earnings event — at a glance, with rule-of-thumb signals.

Key ratios

P/E
-6.0How much investors are paying per dollar of profit the company actually earned in the last 12 months. Lower means the stock looks cheaper relative to earnings.~15–25 is typical for the S&P 500; high-growth names trade 30+; hyper-growth or speculative can be 100+ or negative.
ROIC
-57.2%What percentage return the business earns on every dollar of capital (equity + debt) deployed in operations. The cleanest measure of business quality.Above ~15% is high-quality; consistently above 25% suggests a real moat. Below the company's cost of capital is value-destroying.
Op margin
0.0%Operating profit (after sales, marketing, R&D, and overhead but before interest and taxes) as a percentage of revenue. The clearest view of how well the underlying business is run.Mature business above 20% is healthy; software businesses can run 30%+; commodity / retail businesses operate in single digits.
FCF yield
-6.1%Free cash flow (operating cash flow minus capex) divided by the company's market cap. The cash-on-cash return you'd get owning the whole business at today's price.Above ~5% is attractive; below ~2% means you're paying up for growth. Capital-light businesses (software) run higher than capital-heavy ones (utilities).
P/S
0.0Same idea as P/E but per dollar of revenue. Useful for companies that aren't profitable yet, where P/E is meaningless.Under ~2 is cheap; software / SaaS often runs 8–15; well above 20 implies the market is pricing in very high future growth.
ROE
-58.0%Net income as a percentage of shareholders' equity. Similar to ROIC but counts only the equity side.Above 20% is strong, but can be inflated by leverage — a heavily indebted company can show high ROE with weak underlying ROIC.
Gross margin
0.0%Revenue minus the direct cost of producing what was sold, as a percentage of revenue. The first read on whether the product is structurally profitable.Software / SaaS is typically 70%+; consumer goods 30–50%; commodity / hardware businesses can be under 20%.
D/E
0.2Total debt divided by shareholders' equity. Measures how much the business runs on borrowed money versus owner capital.Under 1 is conservative; 1–2 is typical for mature businesses; over 2 is leveraged and more sensitive to interest rates.

Past earnings

QuarterReportedActualEstimateSurprise
Q2 2026Aug 12, 2026$-2.85$-0.55-419.5%
Q1 2026May 6, 2026$-0.47$-0.51+7.8%
Q4 2025Mar 12, 2026$-0.40$-0.52+22.5%
Q3 2025Nov 10, 2025$-0.52$-0.66+21.2%
Next earningsMon, Nov 9·consensus EPS $-0.53

Quarterly trend

QuarterRevenueYoYGrossOpEPSFCF
Q2 FY26$0———$-2.85$-32.6M
Q1 FY26$0———$-0.47$-39.5M
Q4 FY25$0———$-0.40$-37.9M
Q3 FY25$0———$-0.52$-28.9M

Forward consensus

5-year forecast · up to 7 analysts
FYRevenueRangeEPSRangeAnalysts
FY26$557K$323K – $948K-$2.31-$2.54 – -$2.115
FY27$121.4M$110.3M – $132.5M-$2.10-$3.87 – $1.375
FY28$254.7M$133.0M – $358.4M-$1.17-$2.25 – -$0.217
FY29$682.0M$395.7M – $1.2B$1.95$0.89 – $3.733
FY30$1.1B$655.3M – $1.9B$4.42$2.01 – $8.455

Setup & momentum

Volume, range, and moving-average position — the technical setup driving short-term moves.

Right now

Vol vs 30dToday's traded share volume divided by the average over the prior 30 trading days. ≥3× signals unusual interest; below 1× is quiet.1.3×Today's traded share volume divided by the average over the prior 30 trading days. ≥3× signals unusual interest; below 1× is quiet.
52w rangeWhere the latest close sits between the 52-week low (0%) and high (100%). Above 80% is extended; below 30% is basing or in a downtrend.33%Where the latest close sits between the 52-week low (0%) and high (100%). Above 80% is extended; below 30% is basing or in a downtrend.
vs 50d MALatest close vs the 50-day simple moving average. Positive = short-term trend is up.-4.3%Latest close vs the 50-day simple moving average. Positive = short-term trend is up.
vs 200d MALatest close vs the 200-day simple moving average. Positive = long-term trend is up.-14.2%Latest close vs the 200-day simple moving average. Positive = long-term trend is up.

Float & profile

FloatMid float · 61.9M shFree-float shares — the slice of issued stock actually available to trade. Lower buckets squeeze harder on a catalyst.Traded today1.5% of floatToday's volume as a percent of the free float. Above 5% on a single day is unusually high turnover for the available share count.β0.685-year weekly beta vs the S&P 500. Above 1.5 means the stock typically moves more than the index; below 0.8 moves less.

Insider activity

Recent open-market buys and sells by officers and directors — flagged when multiple insiders cluster.

Recent transactions

SellAug 21Eric WarrenChief Commercial Officer7.4K sh$193KSellAug 10Rodman David MalcomChief Medical Officer2.2K sh$59KSellJul 21Eric WarrenChief Commercial Officer7.4K sh$200KSellJul 17Rodman David MalcomChief Medical Officer416 sh$11KSellJul 15Rodman David MalcomChief Medical Officer6.3K sh$169KSellJul 13Jon CongletonCEO10.7K sh$291KSellJul 13Rodman David MalcomChief Medical Officer14.1K sh$388KSellJul 9Rodman David MalcomChief Medical Officer2.2K sh$66KSellJun 30Jon CongletonCEO75.0K sh$2.0MSellJun 26Eric WarrenChief Commercial Officer104.1K sh$2.7M
1–10 of 16
+ 15 other (14 exempts · 1 award) in window

See when $MLYS insiders are putting their own money in

  • Real-time open-market buys and sells from Form 4 filings
  • Cluster-buy detection when multiple insiders pile in at once
  • 30 / 60 / 180-day windows so you can spot building conviction
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SEC filings

Material 8-K, 13D, S-3, and 424B5 events from the last 180 days — the filings that actually move the price.

Recent material filings

3New insider — initial holdingsAug 123
AI summary

James J. Ferguson III filed an initial Form 3 disclosing his role as Chief Medical Officer at Mineralys Therapeutics, Inc., effective August 10, 2026. Mineralys is a clinical-stage biopharmaceutical company focused on cardiometabolic diseases. No securities are currently beneficially owned, per the filing. The appointment of a CMO is a standard operational step for a clinical-stage company advancing its drug pipeline.

8-KOfficer or director changeAug 118-K — Item 2.02: Earnings release · Item 5.02: Officer or director change
AI summary

Mineralys Therapeutics (MLYS), a clinical-stage biopharma focused on cardiorenal and metabolic diseases, reported Q2 2026 financial results and a corporate update. Separately, the board appointed James J. Ferguson III, M.D. as Chief Medical Officer effective August 10, 2026, replacing David Rodman, M.D., who transitions to a full-time Strategic Advisor role and is no longer classified as an executive officer under SEC rules. An amendment to Dr. Rodmans employment agreement was executed to reflect the new arrangement. The CMO transition during an active clinical development phase is a meaningful leadership signal for a company whose pipeline advancement is a primary investor focus.

424B5Prospectus supplement (offering)Jun 3424B5
8-KMaterial agreementJun 38-K — Item 1.01: Material agreement · Item 2.03: Material debt obligation
8-KShareholder voteMay 228-K — Item 5.07: Shareholder vote
8-KPress release / Reg FDMar 98-K — Item 7.01: Press release / Reg FD · Item 8.01: Other event
+ 10 other (2 10-Qs · 2 earnings 8-Ks · 2 proxys · 1 13G) in window

Recent news

Latest headlines from major outlets, sourced and timestamped — context for whatever just moved.

Canada Pension Plan Investment Board Buys New Holdings in Mineralys Therapeutics, Inc. $MLYSdefenseworld.net·2d agoBlackRock Inc. Buys New Position in Mineralys Therapeutics, Inc. $MLYSdefenseworld.net·5d agoMineralys Therapeutics to Participate in the Wells Fargo 21st Annual Healthcare Conferenceglobenewswire.com·8d agoMineralys Therapeutics Reports Inducement Award Under Nasdaq Listing Rule 5635(c)(4)globenewswire.com·20d agoMineralys Therapeutics, Inc. (MLYS) Q2 2026 Earnings Call Transcriptseekingalpha.com·22d ago

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