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OPOPK

OPKO Health, Inc.

$OPK·$1.0B·Biotechnology·Healthcare
$1.47-0.7%YTD+4.0%1Y+8.1%
Mentions · last 7 days
2026-08-22: 0 posts40%
Price updated 7h ago·X counts updated 9d ago
OPOPK
$OPKOPKO Health, Inc.
$1.47-0.68%4 posts0%
AI analysisFundamentalsVoices on X
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AI verdict & sentimentAI analysisGenerated by AI from underlying data

Today's AI verdict on what's driving $OPK, plus how loud the X conversation is and which way it's leaning.

AI analysis

TickerTalks’ read on the fundamentals and what’s driving the move.

Comeback attemptWinding up for a moveAI verdict · as of 2026-08-20

Trading in a tight range and building pressure — a move looks likely soon, but the direction isn't clear yet.

OPKO Health monetizing Mazdutide royalty in a $125M non-dilutive financing — Frost's fresh 13.9% stake anchors the setup.

OPKO Health is a diversified healthcare company — BioReference Health diagnostics laboratory business, a growing pharmaceutical franchise (Rayaldee for kidney disease), and equity/royalty stakes in partnered programs including Mazdutide (Innovent's GLP-1). The story is a slow-motion turnaround where the Mazdutide royalty is unlocking hidden value.

  • The $125M royalty-secured financing is the tape event: OPKO closed $125M in additional senior secured notes secured by Mazdutide royalty interests — this is non-dilutive capital that monetizes a portion of the royalty stream at premium terms, and the deal validates the market's Mazdutide-royalty value.
  • Chairman Phillip Frost's fresh SC 13D is the anchor: Frost et al. filed a new SC 13D disclosing 13.9% beneficial ownership on Aug 7 — this is the founding chairman formally acknowledging a meaningful position, which is the specific insider signal that historically anchors OPKO tape.
  • The Q2 revenue was mixed but EPS improved: revenue grew 4.3% year-on-year to $164M with gross margin at 49% (up from 42%) — the top line is finally stabilizing, and Q2 EPS beat consensus by 87% (small numbers) shows the operating-leverage math is starting to work.

Trajectory is coiling at 64% of the 52-week range as the tape processes the Mazdutide-monetization event; the Nov 4 Q3 print needs continued revenue stabilization plus commentary on remaining Mazdutide royalty potential — a diagnostic-lab softness or a Mazdutide-related development setback breaks the setup back toward $1.20.

What to watch: Nov 4 Q3 earnings — continued revenue stabilization plus commentary on remaining Mazdutide royalty potential sustains the setup; a diagnostic-lab softness or a Mazdutide-related development setback breaks the setup back toward $1.20.

On the calendar: 2026-11-04 — Q3 2026 earnings

royalty monetization recentno sentiment

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What it does

Plain-English summary of the business — what they sell and how they make money.

Diagnostics and specialty pharma company with US lab services, growth hormone therapy, and international operations.

Industry overviewAI analysisGenerated by AI from underlying data

Where Biotechnology sits in its cycle right now — and what that implies for $OPK.

Biotechnology · Healthcare

GLP-1 oral formulation competition — emerging clinical data from pipeline challengers — is the central bifurcation: platform holders (LLY, NVO) defend on efficacy breadth while precision oncology names decouple entirely. FDA catalyst cadence over the next 60 days sets the near-term tone.

What this means for $OPK

Partial — fee-based midstream revenue has limited direct commodity price exposure but volume ties to upstream production activity.

Top industry ETF

$IBBiShares Biotechnology ETF
+12.1%YTD
+48.9%1Y

Fundamentals & catalyst

Profitability, valuation, and the next earnings event — at a glance, with rule-of-thumb signals.

Key ratios

P/E
-17.7How much investors are paying per dollar of profit the company actually earned in the last 12 months. Lower means the stock looks cheaper relative to earnings.~15–25 is typical for the S&P 500; high-growth names trade 30+; hyper-growth or speculative can be 100+ or negative.
ROIC
-8.0%What percentage return the business earns on every dollar of capital (equity + debt) deployed in operations. The cleanest measure of business quality.Above ~15% is high-quality; consistently above 25% suggests a real moat. Below the company's cost of capital is value-destroying.
Op margin
-25.5%Operating profit (after sales, marketing, R&D, and overhead but before interest and taxes) as a percentage of revenue. The clearest view of how well the underlying business is run.Mature business above 20% is healthy; software businesses can run 30%+; commodity / retail businesses operate in single digits.
FCF yield
-10.8%Free cash flow (operating cash flow minus capex) divided by the company's market cap. The cash-on-cash return you'd get owning the whole business at today's price.Above ~5% is attractive; below ~2% means you're paying up for growth. Capital-light businesses (software) run higher than capital-heavy ones (utilities).
P/S
2.1Same idea as P/E but per dollar of revenue. Useful for companies that aren't profitable yet, where P/E is meaningless.Under ~2 is cheap; software / SaaS often runs 8–15; well above 20 implies the market is pricing in very high future growth.
ROE
-5.9%Net income as a percentage of shareholders' equity. Similar to ROIC but counts only the equity side.Above 20% is strong, but can be inflated by leverage — a heavily indebted company can show high ROE with weak underlying ROIC.
Gross margin
42.3%Revenue minus the direct cost of producing what was sold, as a percentage of revenue. The first read on whether the product is structurally profitable.Software / SaaS is typically 70%+; consumer goods 30–50%; commodity / hardware businesses can be under 20%.
D/E
0.1Total debt divided by shareholders' equity. Measures how much the business runs on borrowed money versus owner capital.Under 1 is conservative; 1–2 is typical for mature businesses; over 2 is leveraged and more sensitive to interest rates.

Past earnings

QuarterReportedActualEstimateSurprise
Q2 2026Jul 27, 2026$-0.01$-0.08+87.5%
Q1 2026Apr 28, 2026$-0.07$-0.070.0%
Q4 2025Feb 26, 2026$-0.04$-0.07+42.9%
Q3 2025Oct 29, 2025$0.03$-0.02+250.0%
Next earningsWed, Nov 4·consensus EPS $-0.06

Quarterly trend

QuarterRevenueYoYGrossOpEPSFCF
Q2 FY26$163.6M+4.3%48.9%-4.3%$-0.01$-46.5M
Q1 FY26$124.2M-17.2%21.6%-41.1%$-0.07$-21.1M
Q4 FY25$148.4M-19.2%30.3%-25.8%$-0.04$-28.6M
Q3 FY25$151.7M-12.6%20.0%-35.3%$0.03$-37.8M

Forward consensus

5-year forecast · up to 5 analysts
FYRevenueRangeEPSRangeAnalysts
FY26$565.4M$547.2M – $575.6M-$0.24-$0.33 – -$0.195
FY27$585.5M$567.5M – $604.1M-$0.28-$0.36 – -$0.225
FY28$606.8M$605.2M – $608.4M-$0.10-$0.21 – $0.002
FY29$651.4M$630.4M – $669.9M-$0.20-$0.21 – -$0.191
FY30$700.2M$677.6M – $720.1M-$0.19-$0.20 – -$0.181

Setup & momentum

Volume, range, and moving-average position — the technical setup driving short-term moves.

Right now

Vol vs 30dToday's traded share volume divided by the average over the prior 30 trading days. ≥3× signals unusual interest; below 1× is quiet.0.6×Today's traded share volume divided by the average over the prior 30 trading days. ≥3× signals unusual interest; below 1× is quiet.
52w rangeWhere the latest close sits between the 52-week low (0%) and high (100%). Above 80% is extended; below 30% is basing or in a downtrend.65%Where the latest close sits between the 52-week low (0%) and high (100%). Above 80% is extended; below 30% is basing or in a downtrend.
vs 50d MALatest close vs the 50-day simple moving average. Positive = short-term trend is up.+6.2%Latest close vs the 50-day simple moving average. Positive = short-term trend is up.
vs 200d MALatest close vs the 200-day simple moving average. Positive = long-term trend is up.+14.0%Latest close vs the 200-day simple moving average. Positive = long-term trend is up.

Float & profile

FloatHigh float · 323.7M shFree-float shares — the slice of issued stock actually available to trade. Lower buckets squeeze harder on a catalyst.Traded today0.7% of floatToday's volume as a percent of the free float. Above 5% on a single day is unusually high turnover for the available share count.β1.495-year weekly beta vs the S&P 500. Above 1.5 means the stock typically moves more than the index; below 0.8 moves less.

Insider activity

Recent open-market buys and sells by officers and directors — flagged when multiple insiders cluster.

Recent transactions

BuyMar 20John A PaganelliDirector10.0K sh$11K
+ 9 other (7 awards · 2 inkinds) in window

See when $OPK insiders are putting their own money in

  • Real-time open-market buys and sells from Form 4 filings
  • Cluster-buy detection when multiple insiders pile in at once
  • 30 / 60 / 180-day windows so you can spot building conviction
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SEC filings

Material 8-K, 13D, S-3, and 424B5 events from the last 180 days — the filings that actually move the price.

Recent material filings

8-KMaterial agreementAug 148-K — Item 1.01: Material agreement · Item 2.03: Material debt obligation
AI summary

OPKO Health, Inc. issued $125 million in additional senior secured notes on August 13, 2026 via an amendment to its July 2024 Note Purchase Agreement with HCR Injection SPV, LLC as agent. The notes mature July 17, 2044, bear interest at 3-month SOFR + 7.5% per annum (4.0% floor), with quarterly interest paid from EirGen Pharma's Pfizer profit-share royalties; they are secured by EirGen's royalty interest in mazdutide (Eli Lilly-licensed) and capped at $187.5M in Mazdutide repayments. This royalty-monetization financing ties OPKO's debt repayment directly to mazdutide's commercial traction in China, a material and long-dated obligation.

SC 13DActivist position (5%+)Aug 7SC 13D
AI summary

FROST PHILLIP MD ET AL 2 Check the appropriate box if a membe filed a new Schedule 13D disclosing a beneficial ownership position of 13.9% in OPK (OPK) as of 2026-08-07. This is a material ownership disclosure indicating significant shareholder interest that may signal activist or strategic intent. Investors should monitor for further 13D amendments, which could indicate evolving positions or demands on management.

SC 13D/AActivist amendmentJul 1SC 13D/A
AI summary

FROST PHILLIP MD ET AL filed an amended Schedule 13D for Common Stock, par value $0.01 per share (OPK) beneficially owning 255,429,406 shares. Reported for potential strategic or activist purposes. SC 13D is required when a beneficial owner crosses 5% with active intent. This amendment updates a prior position. Watch for follow-on disclosures about board engagement, deals, or governance proposals.

8-KShareholder voteJun 188-K — Item 5.07: Shareholder vote
AI summary

OPKO Health, Inc (OPK) reported stockholder vote results (Item 5.07, filed 2026-06-18). Votes covered: director elections, equity plan. Proposals approved by shareholders. Annual votes cover routine governance; material proposals (equity plan expansions) warrant closer review. Check tallies for contested or close votes.

3New insider — initial holdingsMar 203
8-KOfficer or director changeMar 198-K — Item 5.02: Officer or director change
+ 10 other (4 10-Qs · 3 proxys · 2 earnings 8-Ks · 1 ARS) in window

Recent news

Latest headlines from major outlets, sourced and timestamped — context for whatever just moved.

Why Is OPKO Health (OPK) Down 9.7% Since Last Earnings Report?zacks.com·6d agoHere's Why You Should Retain OPK Stock in Your Portfolio for Nowzacks.com·8d agoOPK Raises $125 Million Against Royalties: What Investors Should Knowzacks.com·13d agoIs OPK Worth Buying as Valuation Meets Improving Business Trends?zacks.com·13d agoOPK Climbs 12.4% in the Past Month: Can the Stock Rally Keep Going?zacks.com·13d ago

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