Ionis Pharmaceuticals, Inc.
$81.80+3.3%YTD-0.9%1Y+98.3%
Mentions · last 7 days
67
Price updated 34m ago·X counts updated 23h ago
What it does
Plain-English summary of the business — what they sell and how they make money.
Industry overviewAI analysisGenerated by AI from underlying data
Where Biotechnology sits in its cycle right now — and what that implies for $IONS.
Biotechnology
GLP-1 pipeline competition is the dominant structural driver — the ADA conference crystallized oral formulations, dual agonists, and differentiated mechanisms competing for a potential $150B obesity market by 2030. QURE's FDA accelerated approval for AMT-130 (Huntington's disease) this week confirms gene therapy regulatory momentum is still flowing capital to non-GLP-1 precision medicine.
Top industry ETF
$IBBiShares Biotechnology ETF
+12.1%YTD
+49.0%1Y
Fundamentals & catalyst
Profitability, valuation, and the next earnings event — at a glance, with rule-of-thumb signals.
Key ratios
P/E
-39.8How much investors are paying per dollar of profit the company actually earned in the last 12 months. Lower means the stock looks cheaper relative to earnings.~15–25 is typical for the S&P 500; high-growth names trade 30+; hyper-growth or speculative can be 100+ or negative.ROIC
-11.1%What percentage return the business earns on every dollar of capital (equity + debt) deployed in operations. The cleanest measure of business quality.Above ~15% is high-quality; consistently above 25% suggests a real moat. Below the company's cost of capital is value-destroying.Op margin
-33.3%Operating profit (after sales, marketing, R&D, and overhead but before interest and taxes) as a percentage of revenue. The clearest view of how well the underlying business is run.Mature business above 20% is healthy; software businesses can run 30%+; commodity / retail businesses operate in single digits.FCF yield
-7.4%Free cash flow (operating cash flow minus capex) divided by the company's market cap. The cash-on-cash return you'd get owning the whole business at today's price.Above ~5% is attractive; below ~2% means you're paying up for growth. Capital-light businesses (software) run higher than capital-heavy ones (utilities).P/S
12.4Same idea as P/E but per dollar of revenue. Useful for companies that aren't profitable yet, where P/E is meaningless.Under ~2 is cheap; software / SaaS often runs 8–15; well above 20 implies the market is pricing in very high future growth.ROE
-58.6%Net income as a percentage of shareholders' equity. Similar to ROIC but counts only the equity side.Above 20% is strong, but can be inflated by leverage — a heavily indebted company can show high ROE with weak underlying ROIC.Gross margin
98.3%Revenue minus the direct cost of producing what was sold, as a percentage of revenue. The first read on whether the product is structurally profitable.Software / SaaS is typically 70%+; consumer goods 30–50%; commodity / hardware businesses can be under 20%.D/E
4.2Total debt divided by shareholders' equity. Measures how much the business runs on borrowed money versus owner capital.Under 1 is conservative; 1–2 is typical for mature businesses; over 2 is leveraged and more sensitive to interest rates.Past earnings
QuarterReportedActualEstimateSurprise
Q1 2026Apr 29, 2026$-0.56$-0.85+34.1%
Q4 2025Feb 25, 2026$-1.41$-1.24-14.0%
Q3 2025Oct 29, 2025$-0.61$-1.15+47.0%
Q2 2025Jul 30, 2025$0.86$0.27+218.5%
Next earningsWed, Aug 5·consensus EPS $-0.92
Quarterly trend
QuarterRevenueYoYGrossOpEPSFCF
Q1 FY26$246.1M+87.0%98.8%-47.7%$-0.56$-814.6M
Q4 FY25$203.0M-10.4%96.1%-106%$-1.41$-159.0M
Q3 FY25$156.7M+17.1%98.5%-102%$-0.80$-134.7M
Q2 FY25$452.0M+100.7%99.1%30.9%$0.78$137.1M
Forward consensus
FYRevenueRangeEPSRangeAnalysts
FY26$893.5M$681.2M – $972.8M-$3.61-$3.69 – -$3.4618
FY27$1.5B$1.3B – $1.7B-$1.14-$2.07 – -$0.6118
FY28$2.2B$2.1B – $2.2B$1.43-$4.36 – $5.8017
FY29$2.9B$2.6B – $3.5B$4.62$3.83 – $5.7214
FY30$3.8B$3.3B – $4.4B$7.98$6.60 – $9.878
Setup & momentum
Volume, range, and moving-average position — the technical setup driving short-term moves.
Right now
Vol vs 30dToday's traded share volume divided by the average over the prior 30 trading days. ≥3× signals unusual interest; below 1× is quiet.0.7×Today's traded share volume divided by the average over the prior 30 trading days. ≥3× signals unusual interest; below 1× is quiet.
52w rangeWhere the latest close sits between the 52-week low (0%) and high (100%). Above 80% is extended; below 30% is basing or in a downtrend.84%Where the latest close sits between the 52-week low (0%) and high (100%). Above 80% is extended; below 30% is basing or in a downtrend.
vs 50d MALatest close vs the 50-day simple moving average. Positive = short-term trend is up.+5.1%Latest close vs the 50-day simple moving average. Positive = short-term trend is up.
vs 200d MALatest close vs the 200-day simple moving average. Positive = long-term trend is up.+4.7%Latest close vs the 200-day simple moving average. Positive = long-term trend is up.
Float & profile
β0.375-year weekly beta vs the S&P 500. Above 1.5 means the stock typically moves more than the index; below 0.8 moves less.
Insider activity
Recent open-market buys and sells by officers and directors — flagged when multiple insiders cluster.
Recent news
Latest headlines from major outlets, sourced and timestamped — context for whatever just moved.
IONS Out-Licenses ex-U.S. Rights for Rare Neurology Drug to RecordatiIonis Pharmaceuticals, Inc. (IONS) Discusses FDA Approval of TRYNGOLZA for Severe Hypertriglyceridemia and Acute Pancreatitis Risk Reduction TranscriptFDA Expands IONS' Tryngolza Label to Treat Severe HypertriglyceridemiaIonis Climbs As FDA Clears New Therapy To Lower Triglycerides, Pancreatitis RiskIonis announces license agreement with Recordati for zilganersen in Alexander disease (AxD) in all countries outside the U.S.
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