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AXAXSM

Axsome Therapeutics, Inc.

$AXSM·$11B·Biotechnology·Healthcare
$198.81-0.1%YTD+15.7%1Y+63.5%
Mentions · last 7 days
2026-08-21: 1 posts2026-08-22: 0 posts2026-08-23: 3 posts34-21%
Price updated 6m ago·X counts updated 8d ago
AXAXSM
$AXSMAxsome Therapeutics, Inc.
$198.81-0.11%34 posts-21%
AI analysisFundamentalsVoices on X
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AI verdict & sentimentAI analysisGenerated by AI from underlying data

Top X posts

Today's AI verdict on what's driving $AXSM, plus how loud the X conversation is and which way it's leaning.

AI analysis

TickerTalks’ read on the fundamentals and what’s driving the move.

Driven by hypeAcceleratingAI verdict · as of 2026-08-31

The move is getting stronger, with heavier trading behind it.

Axsome — Q2 revenue +46% YoY to $218M, AUVELITY +51%, new patients 65+ up 126% first 8 weeks, Needham PT $268 Buy, insider Tabuteau sold $10.5M Aug 5-6.

Axsome Therapeutics is a commercial-stage neuroscience biotech — AUVELITY (dextromethorphan-bupropion) for major depressive disorder is the flagship, plus a broader CNS pipeline (Symbravo, AXS-12, AXS-14). The equity is a hot-momentum name whose Q2 print materially validated the commercial ramp.

  • Q2 2026 EPS -$0.99 missed -$0.89 consensus by 11.0% on revenue $216.4M — the EPS miss reflects launch-and-commercialization spend; the important number is Q2 net product revenue of $218.4M (+46% YoY), AUVELITY net product sales $180.3M (+51% YoY), and the ADA (Alzheimer's Disease Agitation) launch showing new-to-brand prescriptions in patients 65+ up 126% in the first eight weeks.
  • The Jul 15 AXS-12 (reboxetine) FDA NDA acceptance for cataplexy in narcolepsy is a specific regulatory-milestone catalyst; the Aug 10 Q2 8-K plus the ADA launch update give the pipeline visibility for the next 12-18 months.
  • Insider tape: Tabuteau exercised 99K M-Exempt on Aug 5-6 at ~$108-$109 and sold 49.7K at ~$212-$214 — a 2x-realized-value in-the-money option monetization.
  • Fundamentals reflect the commercial-transition: P/E -63, P/S 16.9, ROIC -51%, op margin -25%, debt/equity 3.97 — analyst FY27 EPS $5.26 turns positive, FY28 $14.67 models the operating-leverage inflection.
  • Management guides AUVELITY peak revenue at ~$4B (vs Cantor's $2.9B and prior consensus $2B) with Needham raising the price target to $268 Buy and BofA modeling $1.7B revenue and $5-$6 EPS in 2027 — the sell-side is validating the peak-sales bull case.

What extends the run is Q3 revenue topping $220M plus any Symbravo or AXS-12 label-expansion news — both ratify the commercial-scale-plus-pipeline thesis. What breaks it is an ADA launch slowdown or a specific generic-competition-timing disclosure for AUVELITY, either of which resets the peak-sales bull case.

Agrees with X sentimentThe bullish X take — Q2 total net product revenue of $218.4M (+46% YoY, small $2.8M vs consensus miss), AUVELITY net product sales $180.3M (+51% YoY), ADA launch new-to-brand prescriptions in patients 65+ up 126% in first eight weeks, management sees ADA peak revenue at ~$4B vs Cantor's $2.9B, Needham raised PT to $268 Buy, BofA models $1.7B revenue and $5-$6 EPS in 2027, CEO signaled one new drug filing per year through 2030 — captures the commercial-ramp-plus-pipeline-cadence setup exactly.

What to watch: Q3 revenue above $220M plus Symbravo or AXS-12 label-expansion news extends the run; an ADA launch slowdown or specific generic-competition-timing disclosure for AUVELITY resets the peak-sales bull case.

On the calendar: 2026-11-02 — Q3 2026 earnings

X sentiment

What the X crowd is saying right now — descriptive, summarised from the day’s posts.

Bullish sentiment12 posts analyzed · as of 2026-08-17

Axsome Therapeutics chatter is bullish - Q2 total net product revenue of $218.4M (+46% YoY, small $2.8M vs consensus miss), AUVELITY net product sales $180.3M (+51% YoY), and the ADA launch shaping up strongly (new-to-brand prescriptions in patients 65+ up 126% in the first eight weeks). Management sees ADA peak revenue at ~$4B (versus Cantor's $2.9B and prior consensus $2B), and Needham raised the price target to $268 (Buy). BofA models $1.7B revenue and $5-$6 EPS in 2027, and the CEO signaled one new drug filing per year through 2030.

Read the AI verdict + X sentiment for $AXSM

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  • Next dated catalyst when there is one (earnings, deal closing, activist clock)
  • X crowd read with bullish/bearish call + post volume
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What it does

Plain-English summary of the business — what they sell and how they make money.

Commercial CNS biotech with Auvelity approved for major depression and Sunosi for narcolepsy, with CNS pipeline.

Industry overviewAI analysisGenerated by AI from underlying data

Where Biotechnology sits in its cycle right now — and what that implies for $AXSM.

Biotechnology · Healthcare

GLP-1 oral formulation competition — emerging clinical data from pipeline challengers — is the central bifurcation: platform holders (LLY, NVO) defend on efficacy breadth while precision oncology names decouple entirely. FDA catalyst cadence over the next 60 days sets the near-term tone.

What this means for $AXSM

Partial — fee-based midstream revenue has limited direct commodity price exposure but volume ties to upstream production activity.

Top industry ETF

$IBBiShares Biotechnology ETF
+12.1%YTD
+51.2%1Y

Fundamentals & catalyst

Profitability, valuation, and the next earnings event — at a glance, with rule-of-thumb signals.

Key ratios

P/E
-63.2How much investors are paying per dollar of profit the company actually earned in the last 12 months. Lower means the stock looks cheaper relative to earnings.~15–25 is typical for the S&P 500; high-growth names trade 30+; hyper-growth or speculative can be 100+ or negative.
ROIC
-50.8%What percentage return the business earns on every dollar of capital (equity + debt) deployed in operations. The cleanest measure of business quality.Above ~15% is high-quality; consistently above 25% suggests a real moat. Below the company's cost of capital is value-destroying.
Op margin
-24.8%Operating profit (after sales, marketing, R&D, and overhead but before interest and taxes) as a percentage of revenue. The clearest view of how well the underlying business is run.Mature business above 20% is healthy; software businesses can run 30%+; commodity / retail businesses operate in single digits.
FCF yield
-0.6%Free cash flow (operating cash flow minus capex) divided by the company's market cap. The cash-on-cash return you'd get owning the whole business at today's price.Above ~5% is attractive; below ~2% means you're paying up for growth. Capital-light businesses (software) run higher than capital-heavy ones (utilities).
P/S
16.9Same idea as P/E but per dollar of revenue. Useful for companies that aren't profitable yet, where P/E is meaningless.Under ~2 is cheap; software / SaaS often runs 8–15; well above 20 implies the market is pricing in very high future growth.
ROE
-260%Net income as a percentage of shareholders' equity. Similar to ROIC but counts only the equity side.Above 20% is strong, but can be inflated by leverage — a heavily indebted company can show high ROE with weak underlying ROIC.
Gross margin
92.6%Revenue minus the direct cost of producing what was sold, as a percentage of revenue. The first read on whether the product is structurally profitable.Software / SaaS is typically 70%+; consumer goods 30–50%; commodity / hardware businesses can be under 20%.
D/E
4.0Total debt divided by shareholders' equity. Measures how much the business runs on borrowed money versus owner capital.Under 1 is conservative; 1–2 is typical for mature businesses; over 2 is leveraged and more sensitive to interest rates.

Past earnings

QuarterReportedActualEstimateSurprise
Q2 2026Aug 10, 2026$-0.99$-0.89-11.0%
Q1 2026May 4, 2026$-1.26$-0.85-48.2%
Q4 2025Feb 23, 2026$-0.71$-0.70-1.4%
Q3 2025Nov 3, 2025$-0.94$-0.82-14.6%
Next earningsMon, Nov 2·consensus EPS $-0.54

Quarterly trend

QuarterRevenueYoYGrossOpEPSFCF
Q1 FY26$191.2M+57.4%92.3%-33.1%$-1.26$-20.8M
Q4 FY25$196.0M+65.0%93.7%-15.0%$-0.56$-18.7M
Q3 FY25$171.0M+63.2%93.0%-27.0%$-0.94$988K
Q2 FY25$150.0M+72.1%91.0%-24.5%$-0.97$-32.4M

Forward consensus

5-year forecast · up to 17 analysts
FYRevenueRangeEPSRangeAnalysts
FY26$977.8M$863.8M – $1.1B-$2.30-$6.22 – -$0.6916
FY27$1.6B$1.2B – $1.9B$5.26-$8.98 – $11.4616
FY28$2.3B$1.7B – $3.4B$14.67-$4.52 – $35.6917
FY29$3.1B$2.6B – $3.9B$24.81$19.34 – $33.2014
FY30$3.8B$3.2B – $4.8B$31.72$24.73 – $42.458

Setup & momentum

Volume, range, and moving-average position — the technical setup driving short-term moves.

Right now

Vol vs 30dToday's traded share volume divided by the average over the prior 30 trading days. ≥3× signals unusual interest; below 1× is quiet.0.6×Today's traded share volume divided by the average over the prior 30 trading days. ≥3× signals unusual interest; below 1× is quiet.
52w rangeWhere the latest close sits between the 52-week low (0%) and high (100%). Above 80% is extended; below 30% is basing or in a downtrend.58%Where the latest close sits between the 52-week low (0%) and high (100%). Above 80% is extended; below 30% is basing or in a downtrend.
vs 50d MALatest close vs the 50-day simple moving average. Positive = short-term trend is up.-12.5%Latest close vs the 50-day simple moving average. Positive = short-term trend is up.
vs 200d MALatest close vs the 200-day simple moving average. Positive = long-term trend is up.+3.1%Latest close vs the 200-day simple moving average. Positive = long-term trend is up.

Float & profile

FloatLow float · 43.6M shFree-float shares — the slice of issued stock actually available to trade. Lower buckets squeeze harder on a catalyst.Traded today1.0% of floatToday's volume as a percent of the free float. Above 5% on a single day is unusually high turnover for the available share count.β0.605-year weekly beta vs the S&P 500. Above 1.5 means the stock typically moves more than the index; below 0.8 moves less.

Insider activity

Recent open-market buys and sells by officers and directors — flagged when multiple insiders cluster.

Recent transactions

SellAug 6Herriot TabuteauCEO4.7K sh$997KSellAug 5Herriot TabuteauCEO45.0K sh$9.5MSellJul 1Herriot TabuteauCEO49.7K sh$11.9MSellJun 11Roger JeffsDirector286 sh$71KSellJun 10Roger JeffsDirector286 sh$70KSellJun 10Susan MahonyDirector300 sh$74KSellJun 10Mark ColemanDirector643 sh$160KSellJun 9Susan MahonyDirector300 sh$71KSellJun 9Nick PizzieCFO33.0K sh$7.9MSellJun 9Herriot TabuteauCEO49.7K sh$12.0M
1–10 of 16
+ 21 other (12 exempts · 9 awards) in window

See when $AXSM insiders are putting their own money in

  • Real-time open-market buys and sells from Form 4 filings
  • Cluster-buy detection when multiple insiders pile in at once
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SEC filings

Material 8-K, 13D, S-3, and 424B5 events from the last 180 days — the filings that actually move the price.

Recent material filings

8-KOfficer or director changeJun 98-K — Item 5.02: Officer or director change
AI summary

Axsome Therapeutics adopted a new Executive Severance Plan effective June 9, 2026, superseding all prior severance plans and individual employment agreement severance terms. Under the plan, Tier 1 (CEO) receives 18 months of base salary upon involuntary termination (including good reason resignation); Tier 2 (other Section 16 officers) receives 12 months; Tier 3 (VPs and above) receives 6 months — each paid in equal installments over the applicable period, with enhanced terms during a Change in Control period. The plan standardizes severance terms across Axsome's management tier, representing a governance improvement with modest incremental financial exposure.

8-KShareholder voteJun 98-K — Item 5.07: Shareholder vote
AI summary

Axsome Therapeutics held its 2026 Annual Meeting with 43,777,536 of 51,439,952 eligible shares represented (~85.1% quorum). Class II directors Mark Saad (28.7M for, 10.3M withheld — ~27% withhold rate) and Susan Mahony, Ph.D. (29.9M for, 9.1M withheld — ~23% withhold rate) were elected for terms through the 2029 annual meeting; Deloitte & Touche LLP was ratified as independent auditor for FY2026. A non-binding say-on-pay proposal was also voted on but results are truncated in the excerpt. The elevated withhold rates (~27% and ~23%) on both director nominees are above typical levels and merit monitoring.

+ 13 other (4 routine 8-Ks · 2 10-Qs · 2 8-Ks · 2 13Gs) in window

Recent news

Latest headlines from major outlets, sourced and timestamped — context for whatever just moved.

Amgen vs. Axsome Therapeutics: Which Healthcare Stock Is a Better Buy in 2026?fool.com·2d agoAxsome Therapeutics Stock Is Up 16% Year to Date. Why Wall Street Thinks It Has Even More Room to Runfool.com·8d agoBlackRock Inc. Invests $759.70 Million in Axsome Therapeutics, Inc. $AXSMdefenseworld.net·9d agoAxsome's Q2 Earnings Meet Estimates, Auvelity Drives Y/Y Revenueszacks.com·20d agoAxsome Therapeutics Q2 Earnings Review: I Just Can't See The Value Propositionseekingalpha.com·20d ago

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TickerTalks is a research tool, not financial advice. We surface social-attention data; we do not make stock recommendations. Past attention is not predictive of future price movements.

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