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ARARWR

Arrowhead Pharmaceuticals, Inc.

$ARWR·$12B·Biotechnology·Healthcare
$84.91-4.2%YTD+35.1%1Y+280.1%
Mentions · last 7 days
2026-08-21: 6 posts2026-08-22: 4 posts2026-08-23: 4 posts2026-08-24: 12 posts49+11%
Price updated 3d ago·X counts updated 7d ago
ARARWR
$ARWRArrowhead Pharmaceuticals, Inc.
$84.91-4.15%49 posts+11%
AI analysisFundamentalsVoices on X
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AI verdict & sentimentAI analysisGenerated by AI from underlying data

Top X posts

Today's AI verdict on what's driving $ARWR, plus how loud the X conversation is and which way it's leaning.

AI analysis

TickerTalks’ read on the fundamentals and what’s driving the move.

Driven by hypeAcceleratingAI verdict · as of 2026-08-26

The move is getting stronger, with heavier trading behind it.

Arrowhead is up 329% t12m into 88% of range — Plozasiran Shasta-3/4 full data in one week is the near-term binary catalyst.

Arrowhead Pharmaceuticals is the RNAi therapeutics developer whose stock has run 329% over 12 months on the Plozasiran (APOC3) and pipeline validation, positioned in the same RNAi group as SLN/IONS/ALNY. The tape is at fresh highs into a specific near-term data catalyst.

  • The near-term catalysts are dated and specific: Plozasiran full data from Shasta-3/4 in one week with no negative surprises expected, ARO-DIMER-PA readout in the same September window (APOC3+PCSK9, one molecule two genes — JPM's SOTP carries zero for it), ESC Congress new-data presentations in Munich, and Sarepta collaboration flows through the rest of 2026 — that's four specific catalysts within a two-month window.
  • The commercial validation is already happening: REDEMPLO (plozasiran) is now available in Germany as a new treatment option for FCS to reduce triglycerides — that's a real-world commercial launch in a specific ex-US market that supports the peak-sales-to-MC compression case; the sample framing 'RNAi as AI-of-biotech' captures the category tailwind.
  • The tape is fully extended and confirming: at 88% of the 52-week range, 5% above the 50-day and 26% above the 200-day on 0.62x normal volume with beta 1.29 — small insider sales (Olukotun $174K, Perry $1.01M) at ~$87 are moderate post-run distribution, and Deutsche Bank $12.16M new investment is the meaningful institutional counter-flow.

The path if this works is Shasta-3/4 full data landing clean plus ARO-DIMER-PA readout supporting the pipeline, taking the tape past $110. What breaks it is a Shasta-3/4 data disappointment or an ARO-DIMER-PA miss — the biotech setup is binary on data flow, and the tape is priced for continuation of positive readouts.

Agrees with X sentimentThe X bulls have the setup right — Plozasiran full data from Shasta-3/4 in one week with no negative surprises expected, ARO-DIMER-PA readout in September window (APOC3+PCSK9), ESC Congress new-data presentations in Munich, Sarepta collaboration flows, RNAi 'AI-of-biotech' comps with SLN/IONS/ALNY, Sarepta 30% short interest teasing MRNA-like moves — and mechanics back the accelerating tape.

What to watch: Shasta-3/4 Plozasiran full data (in one week) plus ARO-DIMER-PA readout in September window — clean readouts extend the tape past $110; a Shasta-3/4 data disappointment or ARO-DIMER-PA miss breaks the accelerating tape back to $60. Nov 24 Q3 earnings (sell-side -$1.52 EPS) matters less than the readout timing.

On the calendar: 2026-11-24 — Q3 earnings (with Shasta-3/4 readout in ~1 week)

X sentiment

What the X crowd is saying right now — descriptive, summarised from the day’s posts.

Bullish sentiment16 posts analyzed · as of 2026-08-30

Arrowhead's thread turns bullish into ESC Congress plozasiran data and a September readout stack. Posters flag ARO-DIMER-PA (APOC3 + PCSK9, one molecule) reading out the same month as MAPT with JPM's SOTP carrying zero for it, positive historical September seasonality, an active hiring push (100 open jobs), and Galileo Biotech Fund increasing its position. Bulls call ARWR 'one of the most interesting RNAi stories in biotech' with an approved drug, Phase 3 in flight and platform optionality.

Read the AI verdict + X sentiment for $ARWR

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What it does

Plain-English summary of the business — what they sell and how they make money.

Biopharmaceutical company developing RNAi therapies for liver disease, hypertriglyceridemia, and rare genetic disorders.

Industry overviewAI analysisGenerated by AI from underlying data

Where Biotechnology sits in its cycle right now — and what that implies for $ARWR.

Biotechnology · Healthcare

GLP-1 oral formulation competition — emerging clinical data from pipeline challengers — is the central bifurcation: platform holders (LLY, NVO) defend on efficacy breadth while precision oncology names decouple entirely. FDA catalyst cadence over the next 60 days sets the near-term tone.

What this means for $ARWR

Partial — upstream oil & gas exposure ties to commodity price cycle; Arrowhead Pharmaceuticals, Inc.

Top industry ETF

$IBBiShares Biotechnology ETF
+12.1%YTD
+51.2%1Y

Fundamentals & catalyst

Profitability, valuation, and the next earnings event — at a glance, with rule-of-thumb signals.

Key ratios

P/E
-34.8How much investors are paying per dollar of profit the company actually earned in the last 12 months. Lower means the stock looks cheaper relative to earnings.~15–25 is typical for the S&P 500; high-growth names trade 30+; hyper-growth or speculative can be 100+ or negative.
ROIC
-11.0%What percentage return the business earns on every dollar of capital (equity + debt) deployed in operations. The cleanest measure of business quality.Above ~15% is high-quality; consistently above 25% suggests a real moat. Below the company's cost of capital is value-destroying.
Op margin
-35.7%Operating profit (after sales, marketing, R&D, and overhead but before interest and taxes) as a percentage of revenue. The clearest view of how well the underlying business is run.Mature business above 20% is healthy; software businesses can run 30%+; commodity / retail businesses operate in single digits.
FCF yield
-0.5%Free cash flow (operating cash flow minus capex) divided by the company's market cap. The cash-on-cash return you'd get owning the whole business at today's price.Above ~5% is attractive; below ~2% means you're paying up for growth. Capital-light businesses (software) run higher than capital-heavy ones (utilities).
P/S
16.9Same idea as P/E but per dollar of revenue. Useful for companies that aren't profitable yet, where P/E is meaningless.Under ~2 is cheap; software / SaaS often runs 8–15; well above 20 implies the market is pricing in very high future growth.
ROE
-55.4%Net income as a percentage of shareholders' equity. Similar to ROIC but counts only the equity side.Above 20% is strong, but can be inflated by leverage — a heavily indebted company can show high ROE with weak underlying ROIC.
Gross margin
100%Revenue minus the direct cost of producing what was sold, as a percentage of revenue. The first read on whether the product is structurally profitable.Software / SaaS is typically 70%+; consumer goods 30–50%; commodity / hardware businesses can be under 20%.
D/E
2.2Total debt divided by shareholders' equity. Measures how much the business runs on borrowed money versus owner capital.Under 1 is conservative; 1–2 is typical for mature businesses; over 2 is leveraged and more sensitive to interest rates.

Past earnings

QuarterReportedActualEstimateSurprise
Q2 2026Aug 4, 2026$-1.36$-1.28-6.3%
Q1 2026May 7, 2026$-0.93$-1.09+14.7%
Q4 2025Feb 5, 2026$0.22$0.60-63.3%
Q3 2025Nov 25, 2025$-0.18$-0.11-61.3%
Next earningsTue, Nov 24·consensus EPS $-1.52

Quarterly trend

QuarterRevenueYoYGrossOpEPSFCF
Q2 FY26$73.7M-86.4%100%-192%$-0.93$81.9M
Q1 FY26$264.0M+10461.3%100%15.5%$0.22$11.3M
Q4 FY25$256.5M—100%17.2%$-0.17$13.0M
Q3 FY25$27.8M—100%-596%$-1.26$-157.1M

Forward consensus

5-year forecast · up to 10 analysts
FYRevenueRangeEPSRangeAnalysts
FY26$463.1M$372.9M – $619.9M-$3.13-$3.86 – -$1.8810
FY27$327.0M$119.0M – $579.6M-$4.37-$6.96 – -$2.1010
FY28$645.2M$341.5M – $1.1B-$2.76-$5.05 – $0.718
FY29$922.2M$560.9M – $1.4B-$1.58-$2.75 – -$0.774
FY30$1.8B$1.1B – $2.8B$3.16$1.55 – $5.514

Setup & momentum

Volume, range, and moving-average position — the technical setup driving short-term moves.

Right now

Vol vs 30dToday's traded share volume divided by the average over the prior 30 trading days. ≥3× signals unusual interest; below 1× is quiet.0.8×Today's traded share volume divided by the average over the prior 30 trading days. ≥3× signals unusual interest; below 1× is quiet.
52w rangeWhere the latest close sits between the 52-week low (0%) and high (100%). Above 80% is extended; below 30% is basing or in a downtrend.86%Where the latest close sits between the 52-week low (0%) and high (100%). Above 80% is extended; below 30% is basing or in a downtrend.
vs 50d MALatest close vs the 50-day simple moving average. Positive = short-term trend is up.+1.6%Latest close vs the 50-day simple moving average. Positive = short-term trend is up.
vs 200d MALatest close vs the 200-day simple moving average. Positive = long-term trend is up.+21.2%Latest close vs the 200-day simple moving average. Positive = long-term trend is up.

Float & profile

FloatMid float · 122.8M shFree-float shares — the slice of issued stock actually available to trade. Lower buckets squeeze harder on a catalyst.Traded today1.0% of floatToday's volume as a percent of the free float. Above 5% on a single day is unusually high turnover for the available share count.β1.295-year weekly beta vs the S&P 500. Above 1.5 means the stock typically moves more than the index; below 0.8 moves less.

Insider activity

Recent open-market buys and sells by officers and directors — flagged when multiple insiders cluster.

Recent transactions

SellAug 18Adeoye Y OlukotunDirector2.0K sh$174KSellAug 18Michael S PerryDirector11.6K sh$1.0MSellMay 12Hongbo LuDirector3.0K sh$228KSellApr 23James C HamiltonChief Medical Officer10.0K sh$750KSellApr 22Apel Daniel JosephCFO13.1K sh$934KSellMar 5James C HamiltonChief Medical Officer10.0K sh$642K
+ 1 other (1 award) in window

See when $ARWR insiders are putting their own money in

  • Real-time open-market buys and sells from Form 4 filings
  • Cluster-buy detection when multiple insiders pile in at once
  • 30 / 60 / 180-day windows so you can spot building conviction
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SEC filings

Material 8-K, 13D, S-3, and 424B5 events from the last 180 days — the filings that actually move the price.

Recent material filings

3New insider — initial holdingsJun 173
AI summary

Matthew Gregory Cohen filed a Form 3 as a newly appointed Director of Arrowhead Pharmaceuticals, Inc. (ARWR), effective June 15, 2026, reporting 0 shares of common stock and no derivative securities beneficially owned. Routine insider ownership disclosure accompanying his board appointment with no financial or operational impact.

8-KOfficer or director changeJun 168-K — Item 5.02: Officer or director change
AI summary

Arrowhead Pharmaceuticals, Inc. (ARWR) appointed Dr. Matt Cohen, M.D., M.B.A. to its Board of Directors effective June 12, 2026, with standard non-employee director compensation and equity awards. Cohen is Managing Director at Vida Ventures and brings 25+ years of healthcare investing experience, including nearly two decades as lead portfolio manager of the JP Morgan Global Healthcare Fund and co-PM of the JP Morgan Small Cap Growth Fund, plus prior roles at healthcare hedge funds and as a surgery resident. Routine but value-adding board appointment adding deep public biotech investment expertise.

8-KShareholder voteMar 208-K — Item 5.07: Shareholder vote
+ 13 other (8 13Gs · 2 earnings 8-Ks · 2 10-Qs · 1 S-8) in window

Recent news

Latest headlines from major outlets, sourced and timestamped — context for whatever just moved.

Arrowhead Pharmaceuticals Presents Phase 3 SHASTA-3 and SHASTA-4 Data Demonstrating Plozasiran Reduced Acute Pancreatitis Events in Patients with Severe Hypertriglyceridemiagurufocus.com·1d agoArrowhead Pharmaceuticals Presents Phase 3 SHASTA-3 and SHASTA-4 Data Demonstrating Plozasiran Reduced Acute Pancreatitis Events in Patients with Severe Hypertriglyceridemiabusinesswire.com·1d agoArrowhead Pharmaceuticals to Present New Clinical Data at the European Society of Cardiology Congressbusinesswire.com·7d agoDeutsche Bank AG Invests $12.16 Million in Arrowhead Pharmaceuticals, Inc. $ARWRdefenseworld.net·8d agoPeople Living with Familial Chylomicronaemia Syndrome (FCS) in Germany Have Access to REDEMPLO® (plozasiran) as a New Treatment Option to Reduce Triglyceridesbusinesswire.com·14d ago

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